The second season of the mockumentary comedy series "St. Denis Medical" has premiered on November 3, 2025 on NBC, and is also streaming on Peacock. Created by Eric Ledgin and Justin Spitzer, the show stars Wendi McLendon-Covey, Allison Tolman, Josh Lawson, Mekki Leeper, Kahyun Kim, Kaliko Kauahi and David Alan Grier.
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"Alex (Allison Tolman), Joyce (Wendi McLendon-Covey), Ron (David Alan Grier) and the whole crew are back. The feel-better comedy returns with the eccentric yet dedicated doctors, nurses and medical staff of an underfunded Oregon hospital scrubbing in for an all-new season of off-the-charts care."
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