THE SECOND BEST HOSPITAL IN THE GALAXY Season 2 Trailer, Images and Poster

The second season of the adult animated sci-fi comedy series "The Second Best Hospital in the Galaxy" has premiered on May 27, 2025 on Prime Video. Created by Cirocco Dunlap, the series follows alien surgeons and best friends Dr. Klak (Keke Palmer) and Dr. Sleech (Stephanie Hsu) as they deal with a variety of cases. The voice cast also includes Kieran Culkin, Natasha Lyonne, Maya Rudolph, Sam Smith, Andrew Dismukes and Abbi Jacobson.

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"From creator Cirocco Dunlap and Executive Producers Maya Rudolph and Natasha Lyonne, The Second Best Hospital in the Galaxy follows daring surgeons (and inseparable best friends) Dr. Sleech and Dr. Klak, where they frequently risk everything to take on the most dangerous cases in the universe. In Season Two of The Second Best Hospital in the Galaxy, doctors Sleech and Klak relish the fame of their recent success until a cyborg journalist starts digging a little too deep into Sleech’s past. The Second Best Hospital in the Galaxy returns May 27 exclusively on Prime Video."